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Анотація
The problem of microelements bioavailability is highlighted and the correct ways of its solution are substantiated as a result of generalization of theoretical aspects of obtaining of the biometals chelate forms. The characteristics of the main biogenic elements, their physiological significance, electrochemical properties are presented. The main examples of the participation of biometals in various biological processes are given. The properties and the structure peculiarities of biometals coordination complexes are considered in detail. It is shown that in obtaining of biometals chelate forms, there is the mutual selectivity and the affinity of biometals and ligands. The main factors of obtaining a hard metal complex are given. Potential bioligands for obtaining bioavailable forms of microelements are detailed. Among them there are amino acids, peptides, proteins, nucleic acids, carbohydrates. The possible character of complexation depending on the nature of the bioligand is indicated. Practical examples of preparation of biometals mixed ligand complexes are given. The expediency of using metabolic products and processing of lactic acid bacteria as promising components of mixed ligand chelate complexes is substantiated. These substances contain in their composition a mass of potential donor atoms that are capable to form covalent and coordination bonds with biomethalles, and also possess high biological and immunotropic activities. The use of this system in the biocoordination compounds of the "metals of life" can provide a synergistic effect of the components, significantly to expand the range of their physiological activity and to increase the degree of assimilation by the body.
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Як цитувати
Kapustyan, A., & Cherno, N. (2017). Chelate forms of biometalls. Theoretical aspects of obtaining and characteristics. Food Science and Technology, 11(1). https://doi.org/10.15673/fst.v11i1.297
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Розділ
Біопроцеси, біотехнологія харчових продуктів, БАР
Посилання
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2. Avtsyin AP, Zhavoronkov F., Rish MA, Strochkova .S. Mikroelementozyi cheloveka: etiologiya, klassifikatsiya, organopatologiya: M.: Med-itsina; 1991.
3. Marth JD. A unified vision of the building blocks of life. Nat Cell Biol.2008; 10(9):1015-1016.
4. Skalny AV, Skalnaya MG. Metal ions as bioelements. Metal ions in biology and medicine. 2011;.11: 14
5. Bioelementology as integrative approach in trace element research. 14th International Symposium On Trace Elements in Man and Ani-mals.China, Hubei, Enshi. 2011; 229
6. Pais I, Jonts JB. The handbook of elements. Boca Raton: St. Lucie Press; 2000..
7. Skalnyiy AV, Rudakov IA. Bioelementyi v meditsine Avtor: Uchebnoe posobie: MIR ONIKS 21 vek; 2004. ISBN 5-329-00930-8
8. Karkischenko NN. Rol mikroelementov v sportivnom pitanii i bezopasnost metallohelatov. Biomedi-tsina. 2013; 2: 12–41
9. Kalyukova EN. Svoystva metallov i ih soedineniy: uchebnoe posobie: Ulyanovsk : UlGTU, 2009; ISBN 978-5-9795-0407-0
10. Loginova NV. Metallokompleksyi v meditsine: ot dizayna k himioterapii i diagnostike: Mn.: BGU; 2006.
11. .Ulahovich NA i dr. Metallyi v zhivyih organizmah. Uchebnoe posobie dlya lektsionnogokursa «Osnovyi bioneorganicheskoy hi-mii»: Kazan: Kazanskiy universitet; 2012.
12. Ulahovich NA. Kompleksyi metallov v zhivyih organizmah. Sorosovskiy obrazovatelnyiy zhurnal. 1997; 8: 27-32.
13. Litvinova TN i dr. Biogennyie elementyi. Kompleksnyie soedineniya: Rostov n/D: Feniks; 2009.
14. Ershov YuA, Popkov AS, Berlyand Yu.i dr. Obschaya himiya. Biofizicheskaya himiya. Himiya biogennyih elementov: M.: Vyissh. Shk; 2000.
15. Neudachina LK, Lakiza NV. Fiziko-himicheskie osnovyi primeneniya koordinatsionnyih soedineniy: [ucheb. posobie]: M-vo obrazovaniya i nauki Ros. Federatsii, Ural. feder. un-t. — Ekaterinburg : Izd Ural. Un-ta; 2014.
16. Barashkov GK. Meditsinskaya bioneorranika. Osnovyi, analitika, klinika: M.: Izdatelstvo BINOM; 2011. ISBN 978-5-9518-0455-6.
17. Kiselev YuM. Dobryinina NA. Himiya koordinatsionnyih soedineniy: M.: Izdatelskiy tsentr «Akademiya», 2007.
18. Skopenko VV, Tsivadze AYu, Savranskiy LI, Garnovskiy AD. Koordinatsionnaya himiya: M.: IKTs «Akademkniga», 2007.
19. Biometalloorganicheskaya himiya / Pod red. Zh.Zhauena: M.:BINOM. Laboratoriya znaniy; 2009.
20. Scheglova NV, Pechnikova AS, Shevchenko AI. Smeshannoligandnyie kompleksyi kobalta (III) s etilendiaminom i etilendiamintetrauksusnoy kislotoy v vodnyih rastvorah Vestnik Kazanskogo tehnologicheskogo universiteta. 2014; 17(17): 56-59
21. Kornev VI, Keppel NV. Smeshanoligandnyie kompleksyi medi (II) s nitrilotriuksusnoy i limonnoy kislotami v vodnomrastvore. vestnik udmurtskogo un-ta. 2009; 2: 25-31
22. Terekhova IV I dr. Investigation of the pH-dependent complex formation between β-cyclodextrin and dipeptide enantiomers by capillary elec-trophoresis and calorimetry. J. Sep. Sci. 2010; 33:. 2499-2505.
23. Semenov AN, Nikolaeva LS, Mamontov MN, Lyapina LA, Pastorova VE, Feofanova MA. Sravnitelnyiy analiz protsessov kompleksoobrazovaniya ionov magniya i kaltsiya s nizkomolekulyarnyim i nefraktsio-nirovannyim geparinom. Zhurn. neorg. him. 2007; 4: 706-712.
24. Semenov AN. Fiziko-himicheskie zakonomernosti obrazovaniya metallokompleksov ionov nekotoryih s-, d- i f-elementov s geparinom. Av-toreferat diss. kand-ta him. Nauk:Tver; 2010.
25. Nikolaeva LS, Semenov AN, Burova LI. Smeshannoligandnoe kompleksoobrazovanie ionov kaltsiya i magniya s geparinom i glitsinom. Zhurn. neorg. himii. 2011; 4: 689 – 696.
26. Zolotuhina NA. Kompleksyi perehodnyih metallov s organicheskimi ligandami polzunovskiy vestnIK. 2015; 4(2): 58-60
27. Medvedeva SA. Arabinogalaktan listvennitsyi – perspektivnaya polimernaya matritsa dlya biogennyih metallov Himiya i kompyuternoe modelirovanie. Butlerovskie soobscheniya. 2002; 7: 45-50
28. Cherno N, Ozolina S, Nikitina O. Preparation and characterization of iron complexes based on polysaccharides from Agaricus bisporus. Vostochno-Evropeyskiy zhurnal peredovyih tehnologiy. ISSN 1729-3774. 2014; 5/11 (71): 52-57. DOI: 10.15587/1729-4061.2014.27614
29. Verma Sh. Equilibrium study and Stability constants of mixed Ligand complexes of Biomolecules and Amino acids with Metal ions by Potenti-ometric method. Research Journal of Chemical Sciences. March 2015; 5(3): 42-48,
30. Belayet MD. Synthesis and characterization of mixed ligand complexes of Co(II) and Fe(III) ions with maleic acid and heterocyclic amines. Journal of Bangladesh Chemical Society. 2012; 25(2): 139-145.
31. Rabindra P and Mohan A. Synthesis and characterization of mixed ligand complexes of bio-metals with pyrimidine nucleoside (uridine) and amino acids Proc. Indian Acad. Sci. (Chem. Sci.). December 2000; 112(6): 593–600
32. Md. Sher Ali. Mixed Ligand Complexes of Co(II) and Ni(II) Containing Organic Acids and Amine Bases as Primary and Secondary Ligands International Journal of Materials Science and Applications. 2015; 4(4): 225-228
33. Gandham Hima Bindu and Gollapalli Nageswara Rao. Mixed ligand complexes of essential metal ions with L-glutamine and succinic acid in sodium dodecyl sulfate-water mixtures J. Serb. Chem. Soc. 2012; 77 (4): 453–463.
34. Scheglova NV, Pechnikova AS, Shevchenko AI, Smotrina TV, Popova TV, Shkodich VF. Smeshannoli-gandnyie kompleksyi kobalta (III) s etilendiaminom i etilendiamintetrauksusnoy kislotoy v vodnyih rastvorah. Vestnik Kazanskogo tehnologicheskogo universiteta. 2014;17: 56-59
35. Baranova NV, Semenov A.N, Feofanova MA, Frantseva YuV. Smeshanoligandnyie kompleksyi ionov Cu2 i Ni2 s vyisokomolekulyarnyim geparinom i nekotoryimi aminokislotami Nauchno-tehnicheskiy vestnik Povolzhya. # 5 2011g. – Kazan: 36-40
36. Kutoley DA, Bezborodko SA, Shtemenko AV. Obrazovanie smeshanoligandnyih kompleksov Cu(II) na osnove kompleksonov sredney dentatnosti NaukovI pratsI DonNTU. SerIya: HImIya I hImIchna tehnologIya. 2013; 1(20): 64-69,
37. Glushanova NA. Biologicheskie svojstva laktobacill. Bjulleten' sibirskoj mediciny. 2003; 4: 50–58
38. Stojanova LG, Ustjugova EA, Netrusov AI. Antimikrobnye metabolity molochnokislyh bakterij: raznoobrazie i svojstva (obzor). Prikladnaja biohimija i mikrobiologija.2012;48(3): 259-275
39. Shenderov BA. Medicinskaja mikrobnaja jekologija i
funkcional'noe pitanie v 3. T 3 Probiotiki i funkcional'noe pitanie. M.: GRANT. 2001; 288.
40. Neschisljaev VA i dr. K voprosu razrabotki probioticheskih preparatov iz kul'tural'noj zhidkosti laktobakterij. 2007; 1-2: 55.
41. Kapustjan AІ, Cherno NK. Perspektivi vikoristannja bіologіchno aktivnih bakterіal'nih gіdrolіzatіv dlja nutrіtivnoї pіdtrimki naselennja z rozladami іmunnoї. Harchova nauka і tehnologіja. 2015; 2(31): 18-25. DOI: 10.15673/2073-8684.31/2015.44263
42. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat. Immunol. 2010; 11: 373–384.
43. Harris G. et al. How the Immune System Recognizes Self and Nonself. Immunoreceptors and Their Signaling. Dordresht, the Netherlands: Springer. 2008; 251.
44. Jessica Humann and Laure L. Lenz. Bacterial peptidoglycan degrading enzymes and their impact on host muropeptide detection. J Innate Im-mun. 2009 ; 1: 88–97. doi:10.1159/000181181
45. Katsuhiko Matsui and Reiko Ikeda Peptidoglycan in combination with muramyldipeptide synergistically induces an interleukin-10-dependentT helper 2-dominant immune response. Katsuhiko Matsui Microbiol Immunol.2014; 58: 260–265. doi: 10.1111/1348-0421.12139
46. Traub S [et al.] MDP and other muropeptides – direct and synergistic effects on the immune system. J. Endotoxin Res. 2006; 12 (2): 69–85.
47. Polovinkina VS, Markov EYu. Immunoadyuvantnyie svoystva muramildipeptida. Byulleten VSNTs SO RAMN. 2012; (83): 149-153
48. Potehina NV. Teyhoevyie kislotyi aktinomitsetov i drugih grampolozhitelnyih bakteriy. Uspehi biologicheskoy himii. 2006; 46: 225–278
2. Avtsyin AP, Zhavoronkov F., Rish MA, Strochkova .S. Mikroelementozyi cheloveka: etiologiya, klassifikatsiya, organopatologiya: M.: Med-itsina; 1991.
3. Marth JD. A unified vision of the building blocks of life. Nat Cell Biol.2008; 10(9):1015-1016.
4. Skalny AV, Skalnaya MG. Metal ions as bioelements. Metal ions in biology and medicine. 2011;.11: 14
5. Bioelementology as integrative approach in trace element research. 14th International Symposium On Trace Elements in Man and Ani-mals.China, Hubei, Enshi. 2011; 229
6. Pais I, Jonts JB. The handbook of elements. Boca Raton: St. Lucie Press; 2000..
7. Skalnyiy AV, Rudakov IA. Bioelementyi v meditsine Avtor: Uchebnoe posobie: MIR ONIKS 21 vek; 2004. ISBN 5-329-00930-8
8. Karkischenko NN. Rol mikroelementov v sportivnom pitanii i bezopasnost metallohelatov. Biomedi-tsina. 2013; 2: 12–41
9. Kalyukova EN. Svoystva metallov i ih soedineniy: uchebnoe posobie: Ulyanovsk : UlGTU, 2009; ISBN 978-5-9795-0407-0
10. Loginova NV. Metallokompleksyi v meditsine: ot dizayna k himioterapii i diagnostike: Mn.: BGU; 2006.
11. .Ulahovich NA i dr. Metallyi v zhivyih organizmah. Uchebnoe posobie dlya lektsionnogokursa «Osnovyi bioneorganicheskoy hi-mii»: Kazan: Kazanskiy universitet; 2012.
12. Ulahovich NA. Kompleksyi metallov v zhivyih organizmah. Sorosovskiy obrazovatelnyiy zhurnal. 1997; 8: 27-32.
13. Litvinova TN i dr. Biogennyie elementyi. Kompleksnyie soedineniya: Rostov n/D: Feniks; 2009.
14. Ershov YuA, Popkov AS, Berlyand Yu.i dr. Obschaya himiya. Biofizicheskaya himiya. Himiya biogennyih elementov: M.: Vyissh. Shk; 2000.
15. Neudachina LK, Lakiza NV. Fiziko-himicheskie osnovyi primeneniya koordinatsionnyih soedineniy: [ucheb. posobie]: M-vo obrazovaniya i nauki Ros. Federatsii, Ural. feder. un-t. — Ekaterinburg : Izd Ural. Un-ta; 2014.
16. Barashkov GK. Meditsinskaya bioneorranika. Osnovyi, analitika, klinika: M.: Izdatelstvo BINOM; 2011. ISBN 978-5-9518-0455-6.
17. Kiselev YuM. Dobryinina NA. Himiya koordinatsionnyih soedineniy: M.: Izdatelskiy tsentr «Akademiya», 2007.
18. Skopenko VV, Tsivadze AYu, Savranskiy LI, Garnovskiy AD. Koordinatsionnaya himiya: M.: IKTs «Akademkniga», 2007.
19. Biometalloorganicheskaya himiya / Pod red. Zh.Zhauena: M.:BINOM. Laboratoriya znaniy; 2009.
20. Scheglova NV, Pechnikova AS, Shevchenko AI. Smeshannoligandnyie kompleksyi kobalta (III) s etilendiaminom i etilendiamintetrauksusnoy kislotoy v vodnyih rastvorah Vestnik Kazanskogo tehnologicheskogo universiteta. 2014; 17(17): 56-59
21. Kornev VI, Keppel NV. Smeshanoligandnyie kompleksyi medi (II) s nitrilotriuksusnoy i limonnoy kislotami v vodnomrastvore. vestnik udmurtskogo un-ta. 2009; 2: 25-31
22. Terekhova IV I dr. Investigation of the pH-dependent complex formation between β-cyclodextrin and dipeptide enantiomers by capillary elec-trophoresis and calorimetry. J. Sep. Sci. 2010; 33:. 2499-2505.
23. Semenov AN, Nikolaeva LS, Mamontov MN, Lyapina LA, Pastorova VE, Feofanova MA. Sravnitelnyiy analiz protsessov kompleksoobrazovaniya ionov magniya i kaltsiya s nizkomolekulyarnyim i nefraktsio-nirovannyim geparinom. Zhurn. neorg. him. 2007; 4: 706-712.
24. Semenov AN. Fiziko-himicheskie zakonomernosti obrazovaniya metallokompleksov ionov nekotoryih s-, d- i f-elementov s geparinom. Av-toreferat diss. kand-ta him. Nauk:Tver; 2010.
25. Nikolaeva LS, Semenov AN, Burova LI. Smeshannoligandnoe kompleksoobrazovanie ionov kaltsiya i magniya s geparinom i glitsinom. Zhurn. neorg. himii. 2011; 4: 689 – 696.
26. Zolotuhina NA. Kompleksyi perehodnyih metallov s organicheskimi ligandami polzunovskiy vestnIK. 2015; 4(2): 58-60
27. Medvedeva SA. Arabinogalaktan listvennitsyi – perspektivnaya polimernaya matritsa dlya biogennyih metallov Himiya i kompyuternoe modelirovanie. Butlerovskie soobscheniya. 2002; 7: 45-50
28. Cherno N, Ozolina S, Nikitina O. Preparation and characterization of iron complexes based on polysaccharides from Agaricus bisporus. Vostochno-Evropeyskiy zhurnal peredovyih tehnologiy. ISSN 1729-3774. 2014; 5/11 (71): 52-57. DOI: 10.15587/1729-4061.2014.27614
29. Verma Sh. Equilibrium study and Stability constants of mixed Ligand complexes of Biomolecules and Amino acids with Metal ions by Potenti-ometric method. Research Journal of Chemical Sciences. March 2015; 5(3): 42-48,
30. Belayet MD. Synthesis and characterization of mixed ligand complexes of Co(II) and Fe(III) ions with maleic acid and heterocyclic amines. Journal of Bangladesh Chemical Society. 2012; 25(2): 139-145.
31. Rabindra P and Mohan A. Synthesis and characterization of mixed ligand complexes of bio-metals with pyrimidine nucleoside (uridine) and amino acids Proc. Indian Acad. Sci. (Chem. Sci.). December 2000; 112(6): 593–600
32. Md. Sher Ali. Mixed Ligand Complexes of Co(II) and Ni(II) Containing Organic Acids and Amine Bases as Primary and Secondary Ligands International Journal of Materials Science and Applications. 2015; 4(4): 225-228
33. Gandham Hima Bindu and Gollapalli Nageswara Rao. Mixed ligand complexes of essential metal ions with L-glutamine and succinic acid in sodium dodecyl sulfate-water mixtures J. Serb. Chem. Soc. 2012; 77 (4): 453–463.
34. Scheglova NV, Pechnikova AS, Shevchenko AI, Smotrina TV, Popova TV, Shkodich VF. Smeshannoli-gandnyie kompleksyi kobalta (III) s etilendiaminom i etilendiamintetrauksusnoy kislotoy v vodnyih rastvorah. Vestnik Kazanskogo tehnologicheskogo universiteta. 2014;17: 56-59
35. Baranova NV, Semenov A.N, Feofanova MA, Frantseva YuV. Smeshanoligandnyie kompleksyi ionov Cu2 i Ni2 s vyisokomolekulyarnyim geparinom i nekotoryimi aminokislotami Nauchno-tehnicheskiy vestnik Povolzhya. # 5 2011g. – Kazan: 36-40
36. Kutoley DA, Bezborodko SA, Shtemenko AV. Obrazovanie smeshanoligandnyih kompleksov Cu(II) na osnove kompleksonov sredney dentatnosti NaukovI pratsI DonNTU. SerIya: HImIya I hImIchna tehnologIya. 2013; 1(20): 64-69,
37. Glushanova NA. Biologicheskie svojstva laktobacill. Bjulleten' sibirskoj mediciny. 2003; 4: 50–58
38. Stojanova LG, Ustjugova EA, Netrusov AI. Antimikrobnye metabolity molochnokislyh bakterij: raznoobrazie i svojstva (obzor). Prikladnaja biohimija i mikrobiologija.2012;48(3): 259-275
39. Shenderov BA. Medicinskaja mikrobnaja jekologija i
funkcional'noe pitanie v 3. T 3 Probiotiki i funkcional'noe pitanie. M.: GRANT. 2001; 288.
40. Neschisljaev VA i dr. K voprosu razrabotki probioticheskih preparatov iz kul'tural'noj zhidkosti laktobakterij. 2007; 1-2: 55.
41. Kapustjan AІ, Cherno NK. Perspektivi vikoristannja bіologіchno aktivnih bakterіal'nih gіdrolіzatіv dlja nutrіtivnoї pіdtrimki naselennja z rozladami іmunnoї. Harchova nauka і tehnologіja. 2015; 2(31): 18-25. DOI: 10.15673/2073-8684.31/2015.44263
42. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat. Immunol. 2010; 11: 373–384.
43. Harris G. et al. How the Immune System Recognizes Self and Nonself. Immunoreceptors and Their Signaling. Dordresht, the Netherlands: Springer. 2008; 251.
44. Jessica Humann and Laure L. Lenz. Bacterial peptidoglycan degrading enzymes and their impact on host muropeptide detection. J Innate Im-mun. 2009 ; 1: 88–97. doi:10.1159/000181181
45. Katsuhiko Matsui and Reiko Ikeda Peptidoglycan in combination with muramyldipeptide synergistically induces an interleukin-10-dependentT helper 2-dominant immune response. Katsuhiko Matsui Microbiol Immunol.2014; 58: 260–265. doi: 10.1111/1348-0421.12139
46. Traub S [et al.] MDP and other muropeptides – direct and synergistic effects on the immune system. J. Endotoxin Res. 2006; 12 (2): 69–85.
47. Polovinkina VS, Markov EYu. Immunoadyuvantnyie svoystva muramildipeptida. Byulleten VSNTs SO RAMN. 2012; (83): 149-153
48. Potehina NV. Teyhoevyie kislotyi aktinomitsetov i drugih grampolozhitelnyih bakteriy. Uspehi biologicheskoy himii. 2006; 46: 225–278